Close-up of rare whiskey and global spirits on display behind the bar at Myrtle’s in Sioux Falls, highlighting a curated top-shelf collection.

Rare Spirits, Poured with Purpose

Myrtle’s is home to one of the most distinctive spirit collections in Sioux Falls—featuring rare whiskey, vintage liqueurs, and global pours served with purpose and precision.

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Close-up of Myrtle’s signature Old Fashioned bourbon cocktail with citrus peel garnish, served in the downtown Sioux Falls bar.

Bottles You Can’t Find Anywhere Else

From single-barrel bourbons and age-stamped Scotch to limited-batch mezcal, our shelves feature rare and allocated bottles from around the globe—each chosen for character and story.

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Bartender pouring a handcrafted cocktail over hand-cut ice at Myrtle’s Bar in downtown Sioux Falls.

Bartender’s Selections & Collector Favorites

Ask our team for personal favorites, curated flights, or reserve pours. Our bartenders are happy to guide you through the collection—neat, over hand-cut ice, or in a vintage-forward cocktail.

Bartender at Myrtle’s Fur Vault & Bar in Sioux Falls pouring two cocktails made with rare spirits and botanicals from the bar’s curated collection

Curated for Connoisseurs

Whether you’re a seasoned collector or just curious to sip something exceptional, Myrtle’s offers a rare opportunity to explore spirits you’d usually only read about.

Exposed original brick wall inside Myrtle’s Bar, restored from the historic Fry Building in downtown Sioux Falls after 40 years behind drywall.

Unrivaled Spirits & Rare Whiskeys

From small-batch bourbon and single malt Scotch to rare Japanese whisky, our vault is built for true connoisseurs. Book a private tasting curated by legendary mixologist Paul Squyer in Myrtle’s hidden speakeasy for an unforgettable experience.

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A Myrtle's "Green Basil" signature martini cocktail on the bar.

Guests toasting with Myrtle’s signature cocktails — Death of a Salesman and the non-alcoholic Adelaide — served with Wagyu beef and a cracked quail egg, crafted by Parker’s Bistro and presented at Myrtle’s Fur Vault and Bar in downtown Sioux Falls.

Myrtle's Dirty Banana dessert cocktail in a coupe glass on white marble at Myrtle’s, layered with banana liqueur and Kahlua – a signature downtown Sioux Falls drink.

Close-up of a beautifully plated gourmet seafood entrée featuring vibrant greens and rich browns on a white plate — crafted by the chefs at Parker’s Bistro, one of the best restaurants in Sioux Falls, and served at Myrtle’s Fur Vault and Bar.

A vibrant Negroni and Myrtle’s signature Blackthorne Sour rest on a white marble table on the front patio at Myrtle’s Fur Vault and Bar in downtown Sioux Falls

Vertical close-up of Myrtle’s signature Espresso Martini, crafted with Chopin Potato Vodka, J. Rieger Caffe Amaro, The Breaks espresso, and Demerara sugar — garnished with orange peel.

A trio of craft summer cocktails — the Young Alumni, Positive Tension, and 208 Daiquiri — elegantly presented on a white marble patio table at Myrtle’s Bar in downtown Sioux Falls.

A classic barrel aged Old Fashioned served at Myrtle’s Fur Vault and Bar in downtown Sioux Falls — crafted with Woodford Reserve bourbon, demerara sugar, and orange peel. This timeless cocktail glows warmly against the polished wood bar, reflecting Myrtle’s signature approach to refined mixology.

Exterior view of Myrtle’s Fur Vault and Bar on Main Avenue in downtown Sioux Falls, with guests enjoying cocktails beneath a striped awning on a sunny summer day — a standout destination among the best bars in Sioux Falls.

A single yellow cocktail glistens in a coupe glass on a round white table at Myrtle’s Fur Vault and Bar in downtown Sioux Falls — the perfect summer drink at one of the city’s best bars for outdoor cocktails.

Two tall iced summer cocktails with orange and lemon garnishes, glowing in the sun on a marble table — ideal for sipping on the patio at Myrtle’s Fur Vault and Bar, one of the best bars with music in downtown Sioux Falls.

Bright red summer cocktail served in a vintage mason jar, topped with a vibrant green mint garnish — photographed in natural sunlight on the patio at Myrtle’s Fur Vault and Bar, a top speakeasy-style destination in downtown Sioux Falls.

Sins From A Saint cocktail on white marble at Myrtle’s Bar in downtown Sioux Falls — a bold, spirit-forward creation featuring Appleton Estate 8 Year Old, St. Elizabeth Allspice, APerO!, and Tattersall Crème. A must-try at one of the best places for food and cocktails in Sioux Falls.

A single yellow cocktail glistens in a coupe glass on a round white table at Myrtle’s Fur Vault and Bar in downtown Sioux Falls.

The award-winning Rendes Voodoo cocktail at Myrtle’s Fur Vault and Bar in downtown Sioux Falls — crafted with Cantera Negra Añejo Tequila, rooibos-infused Tattersall Blueberry Liqueur, smoked cinnamon, merlot sea salt, and lime, garnished with an edible flower and vibrant skull pic

The Pour Le Rouge cocktail at Myrtle’s Fur Vault and Bar in downtown Sioux Falls — a refreshing blend of Código 1530 Tequila Blanco, Lillet Blanc, Aperol, Tattersall Créme de Fleur, and Fernet-Branca, served over ice with a fresh mint garnish.

Smoky, herbal, and refreshingly bright — Positive Tension is a mezcal-forward signature cocktail at Myrtle’s that balances mango and citrus with a snap of rosemary. A bold favorite in downtown Sioux Falls.

The 208 Daiquiri — a minimalist citrus cocktail served in a chilled coupe glass on a white tabletop on the front patio at Myrtle’s Bar, located next to Parker’s Bistro on Main Avenue in downtown Sioux Falls.

A classic gin martini with olives sits centered on a white patio table at Myrtle’s in downtown Sioux Falls — flanked by a rich Blackthorne Sour and a bold red Negroni, capturing the perfect summer cocktail trio from Parker’s Bistro and Myrtle’s Bar.

A bright red Negroni cocktail with an orange peel garnish, served in a chilled glass glistening with condensation on a white patio table at Myrtle’s Fur Vault and Bar in downtown Sioux Falls — the perfect summer aperitif.

The Lavender Martini at Myrtle’s Fur Vault and Bar in downtown Sioux Falls — a floral-forward gin cocktail made with The Botanist Islay Dry Gin, lavender, and lemon, served elegantly in a chilled martini glass.

The Last Word — a timeless cocktail of gin, green Chartreuse, maraschino liqueur, and lime juice — served in a chilled coupe on a reflective white patio table at Myrtle’s Fur Vault and Bar in downtown Sioux Falls.

A server presents menus to a group of guests seated beneath string lights and teal umbrellas on the outdoor patio at Myrtle’s Fur Vault and Bar — one of the top dining destinations in downtown Sioux Falls.

A ruby red mocktail served in a mason jar and the layered Positive Tension signature cocktail with rosemary garnish, paired with plated dishes at Myrtle’s Fur Vault and Bar in downtown Sioux Falls — a vibrant fusion of flavor and presentation.