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Signature Cocktails in Downtown Sioux Falls

A group of signature cocktails at Myrtle’s bar in downtown Sioux Falls, including mezcal, tiki, and crimson coupe classics with green velvet booth and exposed brick background

Downtown Sioux Falls Cocktails — Award-Winning Recipes, Timeless Atmosphere, and One-of-a-Kind Spirits.

A group of signature cocktails at Myrtle’s bar in downtown Sioux Falls, including mezcal, tiki, and crimson coupe classics with green velvet booth and exposed brick background
A group of signature cocktails at Myrtle’s bar in downtown Sioux Falls, including mezcal, tiki, and crimson coupe classics with green velvet booth and exposed brick background
A group of signature cocktails at Myrtle’s bar in downtown Sioux Falls, including mezcal, tiki, and crimson coupe classics with green velvet booth and exposed brick background
Myrtle's signature cocktail "The New Tango" with woodfords burbon on table and green velvet booth background and exposed brick
Myrtle's signature cocktail "The New Tango" with woodfords burbon on table and green velvet booth background and exposed brick
Myrtle's signature cocktail "The New Tango" with woodfords burbon on table and green velvet booth background and exposed brick

Award Winning Cocktails in a Vintage Bar

From smoked old fashioneds to floral gin sours, every cocktail at Myrtle’s is an experience in mixology. We feature barrel-aged classics, seasonal infusions, and elegant garnishes that reflect the creativity of our bartenders and the spirit of our city.

Three handcrafted cocktails at Myrtle’s: a Lavender Martini with elderflower and lemon, Rendez Voodoo with tequila and blueberry rooibos, and Death of a Salesman with aquavit, cucumber, and garnish
Three handcrafted cocktails at Myrtle’s: a Lavender Martini with elderflower and lemon, Rendez Voodoo with tequila and blueberry rooibos, and Death of a Salesman with aquavit, cucumber, and garnish
Three handcrafted cocktails at Myrtle’s: a Lavender Martini with elderflower and lemon, Rendez Voodoo with tequila and blueberry rooibos, and Death of a Salesman with aquavit, cucumber, and garnish

Downtown Sioux Falls Happy Hour with Vintage Vibes

Join us Tuesday through Friday for rotating specials, featured spirits, and one of the most stylish settings in Sioux Falls. It’s the perfect prelude to dinner, a show, or an evening out downtown.

Guests toasting with colorful cocktails during a private dining event at Myrtle’s in downtown Sioux Falls, with chef-driven dishes and vintage decor in view
Guests toasting with colorful cocktails during a private dining event at Myrtle’s in downtown Sioux Falls, with chef-driven dishes and vintage decor in view
Guests toasting with colorful cocktails during a private dining event at Myrtle’s in downtown Sioux Falls, with chef-driven dishes and vintage decor in view

Hosting a Private Event? Let’s Raise the Bar.

From rehearsal dinners to corporate mixers and business presentations, our chef-driven menu and signature cocktails elevate every private event. Whether you're pitching big ideas or celebrating wins, Myrtle’s delivers a memorable setting with tailored menus, bar service, and a space that speaks both style and substance.

Happy hour cocktail flight at Myrtle's sister brand "Dada Gastropub" a more casual option in downtown Sioux Falls.
Happy hour cocktail flight at Myrtle's sister brand "Dada Gastropub" a more casual option in downtown Sioux Falls
Happy hour cocktail flight at Myrtle's sister brand "Dada Gastropub" a more casual option in downtown Sioux Falls

Looking for Something More Laid Back?

If you love bold flavors and creative drinks but prefer a more casual scene, check out our sister concept, DaDa Gastropub. This casual downtown kitchen serves globally inspired comfort food and inventive cocktails, with happy hour specials and live music nearly every night of the week — all in a vibrant, relaxed setting.

Discover What Makes Myrtle’s Unforgettable

From rare spirits and seasonal fare to curated events and giftable moments, Myrtle’s offers something for every kind of celebration—big or small.

GIFTS THAT SIP WITH STYLE

Give a gift they’ll savor—valid at Myrtle’s or Parker’s for cocktails, cuisine, and unforgettable evenings.

Purchase a Gift Card ›

FINE Dinning & SEASONAL FARE

Chef-driven cousine, each made to pair with cocktails and seasons—crafted with purpose and flair.

Review Our Menu ›

Signature Cocktails 

Explore Myrtle’s cocktail menu of bold originals, aged infusions, and timeless classics—crafted with care.

Signature Cocktail Menu ›

Rare Spirits

Explore Myrtle’s cocktail menu of bold originals, aged infusions, and timeless classics — all built on a foundation of rare spirits and expert technique.

Myrtle's Rare Spirits ›
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